ADRM1 anticorps (AA 15-390)

N° du produit ABIN7600108

Cet anticorps anti-ADRM1 est un anticorps Lapin Polyclonal détectant ADRM1 dans WB, ELISA, IHC, IF, ICC et FACS. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour ADRM1 anticorps (AA 15-390) (ABIN7600108)

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADRM1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-ADRM1 anticorps

Épitope: AA 15-390

Fonction: Anti-ADRM1/ARM-1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-ADRM1/ARM-1 Antibody Picoband® (ABIN7600108). Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ADRM1/ARM-1 recombinant protein (Position: S15-K390).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Husnjak, K., Elsasser, S., Zhang, N., Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K. J., Finley, D., Dikic, I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453: 481-488, 2008. 2. Jorgensen, J. P., Lauridsen, A.-M., Kristensen, P., Dissing, K., Johnsen, A. H., Hendil, K. B., Hartmann-Petersen, R. Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J. Molec. Biol. 360: 1043-1052, 2006. 3. Lamerant, N., Kieda, C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 272: 1833-1844, 2005.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur ADRM1

Antigène: ADRM1 (Adrm1) (Adhesion Regulating Molecule 1 (Adrm1))

Autre désignation: ADRM1

Sujet:

Synonyms: Ran-specific GTPase-activating protein,Ran-binding protein 1,RanBP1,RANBP1,

Tissue Specificity: Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.

Background: Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an in effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 42 kDa

ID gène: 11047

UniProt: Q16186

Pathways: Positive Regulation of Endopeptidase Activity